As shown in Figure 6A and Figure S10A (Supporting Information), the expression of pTBK1 and pIRF3 in tumor tissues was dramatically upregulated in EB@MPCM based groups, because EB facilitated MPCM to accumulate at tumor site and form Mn2+ reservoir, leading to effective activation of cGAS‐STING pathway. This evidence concerns the gene CGAS and neoplasm.