In conclusion, EB@MPCM with spatiotemporal synergistic effect effectively activated cGAS‐STING signaling pathway and targeted blockade of PD‐1/PD‐L1 axis on demand, thereby provoking robust anti‐tumor immune response and significantly inhibiting tumor growth as well as prolonging survival in both cold tumor model and hot tumor model. Here, STING1 is linked to neoplasm.