Evidence indicated a correlation between low circulating Igfbp2 levels and metabolic dysfunction, including obesity, dyslipidemia, and IR, in both human and rodent models.[43] Liver is the primary organ responsible for the production of Igfbp2.[44] In HFD‐fed mice, hepatic Igfbp2 was downregulated and negatively associated with TG content. This evidence concerns the gene IGFBP2 and obesity due to melanocortin 4 receptor deficiency.