TP53 and metabolic syndrome: Premature cellular senescence is a state of irreversible cell‐cycle arrest that plays a significant role in the progression of numerous chronic diseases.[66] In this study, we found that the protein expression of cell senescence marker SA‐β‐gal and cell cycle‐related p53, p21, p16, and p27 were enhanced in the liver of offspring with MetS, suggesting paternal BPA exposure drove hepatocytes underwent functional senescence.