The Akt/Ccnd1/p21/p27 pathway was involved in the regulating the proliferation and migration of liver cancer cells.[69] And p27 mediated the cell cycle arrest and cellular senescence in Ccnd1‐depleted breast cancer cells.[70] Hence, apart from p21 signaling, IAL‐miRs suppressed Ccnd1 to facilitate p27 expression, which was proposed as an additional mechanism contributing to hepatocyte‐senescence in the offspring with MetS. Here, AKT1 is linked to liver cancer.