LEPR and metabolic syndrome: To substantiate the hypothesis that sperm IAL‐miRs functioned as molecular messengers, facilitating the intergenerational transmission of MetS by regulating hepatic Lepr signaling, AgomiRs that mimicked the three IAL‐miRs (miR149‐5p, miR150‐5p, and miR700‐5p) were injected into normal zygotes (Figure 4J).