AKT1 and breast cancer: The Akt/Ccnd1/p21/p27 pathway was involved in the regulating the proliferation and migration of liver cancer cells.[69] And p27 mediated the cell cycle arrest and cellular senescence in Ccnd1‐depleted breast cancer cells.[70] Hence, apart from p21 signaling, IAL‐miRs suppressed Ccnd1 to facilitate p27 expression, which was proposed as an additional mechanism contributing to hepatocyte‐senescence in the offspring with MetS.