Overexpressing Pparg in pancreatic β‐cells led to increased islet cell apoptosis, reduced β‐cell mass, and exacerbated obesity‐induced glucose intolerance in mice.[56] More importantly, numerous studies in animal models of obesity and diabetes have reported that increased hepatic expression of Pparg exacerbates hepatic lipid accumulation. The gene discussed is PPARG; the disease is obesity due to melanocortin 4 receptor deficiency.