VHL and neoplasm: Genetic characterization of tumor samples was undertaken using InferCNV (https://github.com/broadinstitute/inferCNV) and Numbat23 (Figure 1B) focusing on previously described recurrent renal cell carcinoma (RCC) “driver” events.16 All ccRCC epithelial cell clusters exhibited loss of heterozygosity of Chr3p encompassing the VHL gene locus.