Consistently, single-nuclei assay for transposase-accessible chromatin using sequencing (ATAC-seq) showed greater chromatin accessibility at CEBPB motifs in EMT-like ccRCC populations and at HNF4A motifs in epithelial-like populations.9 Activities of AP-1 family immediate-early transcription factors (JUN/JUNB also in the core Module-3 and ATF3/FOSB/JUND in the extended list of Module-3-correlated genes) also exhibited intratumor heterogeneity across all 8 tumors. This evidence concerns the gene FOSB and nonpapillary renal cell carcinoma.