We next identified the transcription factors underlying these dysregulated gene programs using epigenetic landscape in silico deletion analysis (LISA).30 HIF-1α, endothelial PAS domain protein 1 (HIF-2α/EPAS1), and aryl hydrocarbon receptor nuclear translocator (HIF-1β/ARNT) binding were enriched at upregulated genes consistent with their known stabilization in ccRCC (Figure 2G). The gene discussed is EPAS1; the disease is nonpapillary renal cell carcinoma.