Consistent with this, analysis of deregulated transcriptional regulators (Figure 2H) showed downregulation of the Module-1-associated transcriptional regulator (HNF4A) at both the RNA and activity level in ccRCC cells and upregulation of Module-2 (CEBPB) and Module-3 (ATF3, FOS/JUN isoforms)-associated transcriptional regulators. This evidence concerns the gene FOS and nonpapillary renal cell carcinoma.