STAT3 is a master regulator of most key hallmarks and enablers of cancer (2–5), including cell proliferation (6), apoptosis resistance (7), metastasis (2), immune evasion (8), tumor angiogenesis (9), epithelial–mesenchymal transition (10), DNA damage response (11), and the Warburg effect (12). The gene discussed is STAT3; the disease is neoplasm.