Immunofluorescence-based co-staining and quantification of p16 (senescence) and IL6 (SASP) dual positive cells in the intestinal mucosa revealed that the reduction in intestinal tumor incidence was accompanied by reduced accumulation of SASP cells in the IR + ABT-263 group, relative to IR + Veh group (Figure 3). Here, CDKN2A is linked to intestinal neoplasm.