RARA and cancer: As an initial test case for studying T2NR interactions, we focused on the heterodimeric partners RARα and RXRα, which are endogenously expressed alongside various other T2NRs in U2OS cells, a well-established cancer cell line for SMT (Hansen et al., 2017; McSwiggen et al., 2019; Figure 1A, Appendix 2—table 1).