CRP and cardiovascular disorder: Malerba et al. (2006) reported that patients with chronic plaque psoriasis had exacerbated plasma homocysteine levels and lower plasma folic acid levels (Malerba et al., 2006). Similar findings were found in patients with PsA (Kural et al., 2003). The combination of aberrantly elevated plasma CRP and homocysteine levels alone were considered to be useful prognostic biomarkers in predicting the severity of cardiovascular disorders in comparison to monitoring CRP and homocysteine levels independently (Yan et al., 2010).