In conclusion, age (> 40 years), sex, race, cigarette smoking, obesity, elevated CRP and LDL-cholesterol levels, and 25(OH)D deficiency are some of the risk factors associated with the pathogenesis of PsA within the context of a South African population consisting of Caucasians and Indians. The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.