Immunoblot analysis confirmed knockout (KO) of TMEM106B (Fig. 5A), and directed expression of DC-SIGN in both 293T control and TMEM106B KO cells increased entry of Ebola virus glycoprotein (EBOV-GP)pp with similar efficiency but had no effect on vesicular stomatitis virus glycoprotein (VSV-G)pp entry (Fig. 5B), indicating that TMEM106B KO did not interfere with lectin-mediated enhancement of infection (Fig. 5B). Here, TMEM106B is linked to infection.