Specifically, the small heat shock protein Hsp27 (HSP27) significantly impacts the assembly dynamics and structure of CK8/CK18 networks (89), and in separate studies, HSP27 has been shown to play a role in the innate immunity of influenza-infected cells by enhancing the inhibitory effect of NS1 on IFN-β expression (98). The gene discussed is KRT18; the disease is influenza.