CYP19A1 and endometriosis: Activated platelets significantly amplify E2 synthesis from endometriotic stromal cells through NF-κB and TGF-β1 pathways, facilitating the upregulation of pivotal hormone synthesis proteins like StAR, HSD3B2, aromatase, and HSD17B1, indicating a feedback loop that exacerbates endometriosis [129,130].