Point mutations in the TP63 gene result in distinct syndromes: ectodermal dysplasia (ED) syndromes, which are ectrodactyly ectodermal dysplasia cleft lip/palate (EEC), ankyloblepharon–ectodermal dysplasia clefting (AEC), acro–dermato–ungual–lacrimal–tooth (ADULT), and limb–mammary syndrome (LMS). Here, TP63 is linked to exstrophy-epispadias complex.