TP63 and triple-negative breast carcinoma: TP63 may play contradictory roles in breast cancer, which may be due to the differential expression of the two isoforms of TP63 in different tumors, with the TAp63 isoform being negligibly expressed in the breast epithelial cells while the pro-tumorigenic ΔNp63 is highly expressed in basal-type triple-negative breast cancer [180].