CLL-1, also known as C-type lectin-like molecule-1, is a type II transmembrane glycoprotein expressed on approximately 92% of AML blasts and leukemia stem cells (LSCs) while being absent on normal CD34+CD38- hematopoietic stem cells (HSCs) [19,20]. The gene discussed is CLEC12A; the disease is acute myeloid leukemia.