Activating receptors such as DNAX accessory molecule-1 (DNAM-1), NKG2D, NKp46, NKp44 and NKp30 lead NK cells to kill tumor cells by secreting perforin and granzyme B. Fas ligand (FasL) and/or TRAIL are responsible for activating the death receptor pathway [78]. This evidence concerns the gene CD226 and neoplasm.