Moreover, osteoclasts release osteopontin, a proangiogenic factor, which cooperates with vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), secreted by MM cells and BM stromal cells, to enhance angiogenesis in the BM microenvironment [116,117,118]. Here, FGF2 is linked to Miyoshi myopathy.