Classical HL accounts for almost 95% of all diagnosed HLs and is characterized by the presence of CD30+ Reed–Sternberg [18], large multinucleated cells derived from B-lymphocytes, embedded in a tumor microenvironment (TME) rich in immune cells [19,20,21], while nodular lymphocyte predominant HL is characterized by the presence of CD20+ lymphocyte-predominant (LP) cells, surrounded by a TME mostly composed of mature lymphocytes [22]. This evidence concerns the gene TNFRSF8 and Hodgkins lymphoma.