Mutations in the NLRP3 gene are responsible for Muckle–Wells syndrome (MWS), chronic infantile neurologic cutaneous syndrome (CINCA), and cryopyrin-associated periodic syndromes (CAPS) [19,36], which present with fevers, aseptic meningitis, arthritis, and cutaneous inflammation of variable severity. Here, NLRP3 is linked to arthritic joint disease.