NLRP3 and Tremor: The occurrence of NLRP3 inflammasome dysregulation was age-dependent: RPMφ from symptomatic and late-stage symptomatic hexb−/− mice of 12 and 14 weeks of age which exhibit multiple disease symptoms including tremor, ataxic gate, muscle weakness, and motor dysfunction [30] aberrantly secreted IL-1β in response to priming alone, whereas Mφ prepared from 8-week-old pre-symptomatic mice displayed canonical, two-signal-dependent IL-1β production.