Furthermore, we have shown histone acetylation aberrancies at the C-X-C chemokine ligand 8 (CXCL8) [12], collagen type XV alpha-1 (COL15A1) [13], and tenascin-C (TNC) [13] promoter regions unique to COPD. The gene discussed is COL15A1; the disease is chronic obstructive pulmonary disease.