Germline mutations of the ANKRD26, RUNX1, and ETV6 genes are associated with three autosomal dominant forms of thrombocytopenias: ANKRD26-Related Thrombocytopenia (ANKRD26-RT), Familial Platelet Disorder with propensity to Acute Myelogenous Leukemia (FPD/AML) and ETV6-Related Thrombocytopenia (ETV6-RT). Here, ETV6 is linked to acute myeloid leukemia.