1,2,3,4,6-O-Pentagalloylglucose 18’s tumor-suppressive activity is attributed to its multiple galloyl groups, which contain hydroxyl groups that specifically bind to the active site of UBE2T, notably at cysteine residue Cys86, with a dissociation constant (KD) of 23.94 nmol/L [116]. The gene discussed is UBE2T; the disease is neoplasm.