Among the HCC patients, a negative correlation was found between the AFP level (rs = −0.21, p = 0.36), tumor grade (rs = −0.51, p = 0.03), tumor size >5 cm (rs = −0.53, p = 0.02), age greater than 70 years (rs = −0.45, p = 0.047) and the number of p-CTCs. This evidence concerns the gene AFP and hepatocellular carcinoma.