ZNF91 and malignant colon neoplasm: ZNF91 is also a key regulator according to CD GRN, along with another 29 TFs, and regulates 374 CD common overregulated DEGs, including TP53TG1, which are co-expressed in CD, colon cancer, and lung adenocarcinoma and are related to transmembrane transport, mitochondrial function, and multiple metabolic pathways and diseases (Table S1.6).