VDR is also a key regulator according to UC GRN, along with 44 other TFs, and regulates 409 UC common overregulated DEGs, including TP53TG1 and SATB2-AS1, which are co-expressed in colon cancer and related to transmembrane transporter activity, phosphorylation, mitochondrial and peroxisome function, PPAR, and multiple metabolic pathways and diseases. Here, PPARA is linked to colonic neoplasm.