Under UC, endoplasmic reticulum stress could be important for efficient hepatitis C virus infection as it influences ERLIN2’s role in lipid raft stability, perhaps regulating the expression of PPARGC1A and PPARGC1B [136], having an impact in lipid metabolism and homeostasis, a process controlled in part by the PPAR signaling pathway [137]. Here, PPARGC1B is linked to hepatitis C virus infection.