PAH and colon cancer have eight (CDC25B, GJA4, MXRA7, S100A11, SLC29A1, SLC3A2, TIMP3, and TRMT1) common overregulated genes located in the nucleoplasm, along with fifteen TFs, the transmembrane helix, lysosomal membrane, and extracellular exosomes, related to negative regulation of cell population proliferation, symbiont entry into host cells, as well as two common overregulated TFs (AEBP1, and ZNF503) located in extracellular exosomes, related to negative regulation of cell population proliferation and transcription. The gene discussed is TRMT1; the disease is pulmonary arterial hypertension.