MDH2 and lung cancer: According to our previous transcriptomic analysis [36], UC and lung cancer have seven (ALDH18A1, CASK, CNTNAP2, DNAJA3, MDH2, PPP2R3A, and PTPRF) common overregulated genes and one TF (BZW2) located in mitochondrion, membrane, and extracellular exosome, and related to metabolic pathways, citrate cycles, carbon, pyruvate, glyoxylate and dicarboxylate metabolism, ATP binding, transit peptides, and epigenetic reprograming through acetylation.