COG2 is in the trans-golgi network membrane; CYP4F12 is in the endoplasmic reticulum membrane and transmembrane helix; NDRG2 is in the golgi apparatus, extracellular exosomes, transmembrane helix, and related to epigenetic reprograming through acetylation; TACO1 is in mitochondrion, related to primary mitochondrial disease; and HOXA2 is in the nucleoplasm along with 14 TFs and related to negative regulation of transcription by RNA polymerase II. The gene discussed is TACO1; the disease is inborn mitochondrial metabolism disorder.