ZNF91 is overregulated in ten CD datasets and eleven UC datasets, while TP53TG1 is overregulated in eight CD datasets and nine UC datasets, suggesting that they might be key regulators of IBD gene expression through transcriptomic and epigenomic mechanisms involved in mitochondrial function and metabolic pathways; however, their function has not been analyzed yet in these inflammatory diseases, neither in its association with microbiome network formation nor its function. Here, ZNF91 is linked to inflammatory bowel disease.