DLG1 is targeted by HPV [140] and the avian influenza virus NS1 ESEV PDZ binding motif [141], which may lead to disrupted epithelial cell junctions and enhanced viral replication, influencing infection in gastrointestinal mucosa in UC, while HPV-18 E7 is also able to increase DLG1 levels, likely by rescuing it from E6-mediated proteasomal degradation [142]. The gene discussed is DLG1; the disease is infection.