PAH upregulated DEGs are related to the function of the extracellular exosomes (AEBP1), plasma membrane (HIF3A and KCNIP3), transmembrane helix (GLMP), cytoplasmic vesicles, lysosome, membrane raft, golgi, endosome, phagosome, and endoplasmic reticulum. This evidence concerns the gene KCNIP3 and pulmonary arterial hypertension.