PFN2 and lung cancer: According to our previous transcriptomic analysis [36], CD and lung cancer have nine (ALDH18A1, DSP, GNG4, LAD1, PFN2, PPP2R3A, PTPRF, and SFXN1) common overregulated genes located in the mitochondrion, extracellular exosome, membrane, and receptor complex related to metabolic pathways, ATP binding, epigenetic reprograming through dephosphorylation, and acetylation.