PPARA and mitochondrial disease: There are 227 common upregulated DEGs between CD and UC, of which 15 are TFs, located in the mitochondrion and extracellular exosomes, related to metabolic pathways, epigenetic reprograming through acetylation, primary mitochondrial disease, fatty acid degradation, peroxisome proliferator-activated receptor (PPAR) and AMP-activated protein kinase (AMPK) signaling pathways, proteoglycans in cancer, and citrate cycles (TCA cycle).