ZNF91 is also a key regulator according to CD GRN, along with another 29 TFs, and regulates 374 CD common overregulated DEGs, including TP53TG1, which are co-expressed in CD, colon cancer, and lung adenocarcinoma and are related to transmembrane transport, mitochondrial function, and multiple metabolic pathways and diseases (Table S1.6). This evidence concerns the gene GRN and malignant colon neoplasm.