VDR is also a key regulator according to UC GRN, along with 44 other TFs, and regulates 409 UC common overregulated DEGs, including TP53TG1 and SATB2-AS1, which are co-expressed in colon cancer and related to transmembrane transporter activity, phosphorylation, mitochondrial and peroxisome function, PPAR, and multiple metabolic pathways and diseases. This evidence concerns the gene VDR and malignant colon neoplasm.