COG2 is in the trans-golgi network membrane; CYP4F12 is in the endoplasmic reticulum membrane and transmembrane helix; NDRG2 is in the golgi apparatus, extracellular exosomes, transmembrane helix, and related to epigenetic reprograming through acetylation; TACO1 is in mitochondrion, related to primary mitochondrial disease; and HOXA2 is in the nucleoplasm along with 14 TFs and related to negative regulation of transcription by RNA polymerase II. This evidence concerns the gene HOXA2 and inborn mitochondrial metabolism disorder.