In addition, the DHHC (Asp‐His‐His‐Cys)‐S‐acyltransferase protein family targets different GSC subsets in specific niches and regulates the plasticity of cells in these subtypes via its interaction with Bmi‐1 to regulate its polyubiquitination, thereby influencing the plasticity of GBM stem cells [68]. The gene discussed is BMI1; the disease is glioblastoma.