BMI1 and neoplasm: Mechanistic investigations identified Bmi‐1 as a functional downstream target of miR‐218, through which miR‐218 ablates cell migration, proliferation, and self‐renewal by regulating genes involved in tumor development (HIF‐1a and PI3K/Akt signaling pathways); it also regulates tumor metabolism, particularly hexokinase‐2 [75, 76].