CDKN2A and neoplasm: Bmi‐1 activates and interacts with NF‐κB to promote angiogenesis and invasion, regulates the INK4a‐ARF locus, and interacts with various microRNAs to influence tumor progression and proliferation. In addition, Bmi‐1 confers radioresistance and chemotherapy by promoting cell senescence evasion and DNA repair.