Exercise volume and intensity-dependent thresholds have been observed to induce changes in circulating PTH concentrations,43 with marked increases following high-intensity endurance exercise but not after shorter or less intense bout of exercise.44 The role of PTH and other mediators of calcium phosphate regulation in the development of coronary atherosclerosis amongst athletes represents an important line of inquiry for future research.45 The gene discussed is PTH; the disease is coronary atherosclerosis.