INS and Insulin resistance: Results of glucose and insulin tolerance tests showed that compared with sham mice, obese mice had the characteristics of glucose intolerance and insulin resistance (Figs. 1H, I), (p < 0.01), while BBR administration improved these conditions of obese mice (Figs. 1H, I), (p < 0.05) at 20 min -120 min (glucose) and 20 min - 100 min.