Regarding the entire period from 1990 to 2023, “major depression” (strength: 225.27) has the highest burst strength, followed by “tumor necrosis factor” (strength: 178.52), “necrosis factor α” (strength: 104.25), “pituitary adrenal axis ” (strength: 92.77), “myocardial infarction” (strength: 89.45) and “coronary heart disease” (strength: 89.36). Here, TNF is linked to major depressive disorder.