SERPINE1 and type 2 diabetes mellitus: Several studies have also shown that the levels of anti-inflammatory molecules like adiponectin are lowered in insulin-resistant stages of type 2 diabetes, even if inflammatory mediators or indicators such as IL-6, TNF-alpha, fibrinogen, high-sensitive CRP, and plasminogen activator inhibitor-1 (PAI-1) have increased [11, 12].