Furthermore, elevated NSUN2 expression in HCC correlates with several genes involved in critical signaling pathways such as Ras and PI3K-Akt, including Growth factor receptor-bound protein 2(GRB2), Ring Finger Protein 115 (RNF115), Apoptosis Antagonizing Transcription Factor (AATF), A Disintegrin And Metalloprotease 15 (ADAM15), Reticulon 3 (RTN3), and Hepatoma-Derived Growth Factor (HDGF) [115]. Here, HDGF is linked to hepatocellular carcinoma.