METTL14 and p53 apoptosis effectors related to PMP-22 (PERP) mRNA are crucial in pancreatic cancer proliferation and metastasis, especially PERP mRNA, whose turnover accelerates post m6A modification, resulting in reduced mRNA and protein expression, thus promoting pancreatic cancer growth and spread [122]. This evidence concerns the gene TP53 and familial pancreatic carcinoma.