The MTase domain of METTL3 is critical for cancer growth, with key motifs (DPPW, IHM, RTGRTGH) that are central to its carcinogenic effects; DPPW acts as a catalytic motif, while RTGRTGH is crucial for the MTase activity of the METTL3-METTL14 complex [91]. This evidence concerns the gene METTL3 and cancer.