TTR and restrictive cardiomyopathy: In this case, the patient’s PYP scan was diagnostic for wild-type ATTR, which typically affects individuals over the age of 65 and is associated with restrictive cardiomyopathy and progressive heart failure [4]. The heart-to-contralateral lung (H/CL) ratio on the PYP scan, combined with the semiquantitative visual score, provided a highly specific and noninvasive means of confirming the diagnosis of ATTR [4].