Moreover, HLA-E/Mtb restricted CD8+ T cells were detected in the circulation of individuals with Mtb infection (TBI) and active TB (aTB) with or without HIV and revealed an unorthodox phenotype reflected by the secretion of T-helper 2 associated cytokines (e.g., IL-4 and IL-13) (16). The gene discussed is CD8A; the disease is tuberculosis.