,55, 56, 57, 58, 59 Cadherin-2 is a phosphorylated substrate of FAM20C and a marker of epithelial-mesenchymal transition, so FAM20C may be involved in epithelial-mesenchymal transition through cadherin-2, thereby influencing related cancers (Figure 2, Figure 3).5 This evidence concerns the gene CDH2 and cancer.