CHST3 and pneumothorax: Furthermore, we performed KEGG disease enrichment analysis on these differential genes, and the results showed that HSD could significantly induce male mouse offsprings to contract pulmonary candidiasis (P = 2.90E-05) (Fig. 5c), while HSD significantly induced female mouse offsprings to contract pneumothorax (P = 2.58E-03) (Fig. 5d).