These factors play a role in alleviating ER stress and apoptosis: zinc‐limited mutants of MSC2, the yeast ortholog of mammalian Znt5, exhibit UPR activation and defective ER‐associated protein degradation; moreover, in chicken DT40 lymphoma cells, double deletions of ZnT5 and ZnT7 induce UPR due to defective zinc sequestration into the ER lumen, suggesting that both excess and deficiency of zinc in the ER could induce ER stress.1 The gene discussed is SLC30A7; the disease is lymphoma.