HDAC6 and Hypercholesterolemia: In this study, we sought to address the following questions: (1) Does HDAC6 inhibition preserve erectile function and penile endothelial function in a model of hypercholesterolemia?, (2) Does HDAC6 inhibition upregulate CSE expression in the hypercholesterolemic corpus cavernosum?, and (3) Does HDAC6 inhibition alter markers of autophagy and mitophagy in the hypercholesterolemic corpus cavernosum?