Tyrosine receptor kinases (EGFR, FGFR1, IGF1R and VEGFR) often were overexpressed in HCC by promoting cell proliferation, survival, migration and angiogenesis and play crucial roles in activation of several signaling pathways (Shi et al., 2020[41]; Hu et al., 2021[20]). Here, IGF1R is linked to hepatocellular carcinoma.