MAP2K1 and melanoma: 2021) and a pharmacological enhancer (Liang et al. 2023). Studies have shown that 10-gingerol inhibits the viability and proliferation of A375 melanoma cells in a dose-dependent manner. Furthermore, it significantly suppresses the phosphorylation levels of proteins such as BRAF, MEK1/2, and P38, without affecting the phosphorylation of ERK1/2. These findings indicate that 10-gingerol may act as a potential inhibitor of melanoma, with its antitumor efficacy potentially linked to the inhibition of BRAF activation (Zhang et al. 2018).