NOLC1 and neoplasm: However, previous studies have demonstrated the regulatory role of CSCs in tumor initiation, metastasis, drug resistance, recurrence, etc. The present study only provides preliminary insights into the mechanism of stemness acquisition in LUAD cells and the effect on cisplatin resistance, while it is uncertain whether the FOXA1/NOLC1 axis can regulate other malignant phenotypes by affecting LUAD cell stemness.