While MOGS enhances NOTCH1 protein maturation and activates the NOTCH pathway by boosting NOTCH1 glycosylation, which in turn promotes stemness acquisition and tumor invasiveness in colorectal cancer,34 TM4SF1 activates the NOTCH pathway by positively regulating MYH9, which in turn promotes hepatocellular carcinoma stemness and enables it to acquire Lenvatinib resistance.35 The gene discussed is NOTCH1; the disease is colorectal cancer.