Considering that INI1 protein plays a critical role in epigenetic regulation, cell cycle progression, and crosstalk between various signaling cascades, loss of INI1 function has been found to upregulate several oncogenic signaling pathways associated with tumor proliferation and progression [18, 32, 33, 34, 35, 36, 37, 38]. The gene discussed is SMARCB1; the disease is neoplasm.