Although the detailed mechanisms by which PANoptosis regulates antitumor immunity vary across different types of cancer, increasing evidence shows that key PANoptosis-related genes (PRGs), such as GSDM family proteins, NOD-like receptor protein 3 (NLRP3), caspase 8, receptor-interacting protein kinases (RIPK)3, and MLKL are highly associated with tumor progression and immune response [39, 40]. Here, CASP8 is linked to cancer.