GSDME and infection: At the molecular level, either wtVSV or VSV-S infection led to the appearance of cleaved caspase 3, caspase 8, and N-terminal gasdermin E (GSDME-N) (Fig. 3E), supporting the notion that VSV can trigger caspase 3/8/GSDME-dependent pyroptosis regardless of SMAC/DIABIO insertion.