APOE and Cognitive impairment: Among APOE ε4 non-carriers, moderate (OR = 0.66, 95%CI = 0.48 ~ 0.92, P-value = 1.43 × 10− 2) and high PA levels (OR = 0.59, 95%CI = 0.46 ~ 0.75, P-value = 2.68 × 10− 5) were significantly associated with lower risk of cognitive impairment compared to low PA levels.