Six patients changed their oral medications: one each for increased pleural effusion, asymptomatic elevation of BNP (SAE), increased arrhythmia, digitalis discontinuation due to atrioventricular block, progressive renal dysfunction due to increased diuretics administered before study entry (SAE) [17], and change in prescription dose due to miscommunication. This evidence concerns the gene NPPB and atrioventricular block.