Concerning the use of alternative hexose sugars (other than glucose) for human cell cultivation, it was recently shown that acute myeloid leukemia cells grown in high-fructose conditions are more dependent on the serine biosynthesis pathway (compared with cells grown in glucose), and that pharmacological inhibition of PHGDH markedly reduces their growth [41]. This evidence concerns the gene PHGDH and acute myeloid leukemia.