Furthermore, RABEP2 acts as a regulatory factor promoting Rab4‐dependent VEGFR2 transport, inhibiting the VEGFR2/PKC/ERK1‐2 signalling pathway, reducing Sph K1 translocation and effectively impeding synovial angiogenesis, thereby alleviating RA progression [50, 51]. This evidence concerns the gene RABEP2 and rheumatoid arthritis.