APC and cancer: However, APC/CCdh1 is also active in G2 allowing DNA-repair prior to mitotic entry (Wasch et al, 2010), whilst untimely APC/C activity may occur in cancer cells, where the SAC is often defective (Teixeira et al, 2014) and the presence of supernumerary centrosomes may cause prolonged mitotic delay (Karki et al, 2017; Kwon et al, 2008).