Whilst no DUBs have previously been reported to regulate KIFC1, candidates from genome-wide screens for centrosome clustering regulators in Drosophila or oral squamous cell carcinoma, included orthologs of USP8 (CG5798) and USP43 (CG30421) (Kwon et al, 2008) and the pseudo-DUB USP54 (Leber et al, 2010). The gene discussed is USP54; the disease is oral cavity squamous cell carcinoma.