An oncolytic vaccinia virus armed with an Epha2-directed BiTE and the oncolytic adenovirus ICOVIR-15K expressing an EGFR-targeting BiTE, respectively, showed robust T-cell activation and bystander cell-mediated cytotoxicity in vitro and in murine tumor models (Yu et al, 2014; Fajardo et al, 2017). This evidence concerns the gene EGFR and neoplasm.