It has been shown that adapter proteins referred to as bispecific T-cell engagers (BiTEs) stimulate antitumoral T-cell activity independent of TCR-specificity, MHC restriction and the need for costimulation which is achieved via binding to CD3ε on T cells and to a defined tumor-specific antigen present on the surface of target tumors (Löffler et al, 2000; Baeuerle and Reinhardt, 2009). This evidence concerns the gene HLA-C and neoplasm.