In addition, it has been reported that estrogen-related receptor α (ERRα) in breast cancer cells interacted with the promoter of Grem1 to promote expression of Grem1, which in turn enhanced the ERRα promoter activity through phosphorylation and activation of EGFR (an upstream regulator of ERRα) to form a positive feedback loop [42]. The gene discussed is ESRRA; the disease is breast carcinoma.