One example is TDP-43, related proteinopathies of which (i.e., nuclear clearance and cytosolic inclusion) are broadly found in about 97% of ALS, 50% of FTD, and 40-60% of AD patients (Ayala et al, 2008; Jo et al, 2020; Meneses et al, 2021). This evidence concerns the gene TARDBP and Alzheimer disease.