Phosphorylation of eIF2α is elevated in AD patients, and suppression of the upstream kinases alleviates plasticity and cognition deficits in AD mouse models (Devi and Ohno, 2014; Lourenco et al, 2013; Ma et al, 2013; Segev et al, 2015; Tible et al, 2019). Here, EIF2A is linked to Alzheimer disease.