A clear line of evidence on repeat RNAs sequestering RBPs and influencing RNA splicing refers to myotonic dystrophy type 1 and 2 (DM1/DM2) where CUG- or CCUG-repeat RNA binds MBNL1–3, muscle or neuron-enriched RBPs. The gene discussed is MBNL1; the disease is myotonic dystrophy type 1.