In myotonic dystrophy type 2 (DM2), a neuromuscular disease involving neuronal loss and global neuronal impairment, pseudouridines within the CCUG repeats in the intron of CNBP decrease repeat RNA dynamics and thus reduce sequestration of MBNL1 to the repeat RNA (deLorimier et al, 2017). This evidence concerns the gene MBNL1 and myotonic dystrophy type 2.