Accumulation of TDP-43 was proposed to account for the mRNA destabilization in the C9ORF72-ALS iPSC model, as a considerable proportion of destabilized transcripts are shared between iPSCs with overexpression of TDP-43 and iPSCs of C9ORF72-ALS (Tank et al, 2018). This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.