STMN2 and amyotrophic lateral sclerosis: Constitutive Stmn2 knockout in mice results in delayed microtubule polymerization and axon outgrowth (Krus et al, 2022), and persistent loss of stathmin-2 in adult mice results in ALS-linked pathologies, including reduced inter-neurofilament spacing, axonal caliber collapse, progressive motor and sensory deficits, and muscle denervation (Lopez-Erauskin et al, 2024; San Juan et al, 2022).