Recent work using cryo-EM has revealed more precise structures and protein components of the aggregates in patient postmortem tissues, such as TAF15 (Tetter et al, 2024) and TDP-43 (Arseni et al, 2023; Arseni et al, 2024) that formed amyloid filaments in different types of FTD. Here, TARDBP is linked to frontotemporal dementia.