Previously reported RCTs demonstrated the potential of zinc supplementation to ameliorate hepatic encephalopathy-related clinical symptoms, as well as to enhance clinical parameters (such as blood albumin, ammonia levels, and Child–Pugh score) or to stop the evolution of the disease (e.g., progression to HCC) (Diglio et al. 2020; Shipley et al. 2019). The gene discussed is ALB; the disease is hepatocellular carcinoma.