Furthermore, zinc suppresses gene expression of α-SMA and collagen I and enhances the capacity of collagen degradation as determined by the increased activity of total collagenases and elevated mRNA and protein levels of MMP13, so zinc supplementation suppresses liver fibrosis through both inhibiting collagen production and enhancing collagen degradation (Shi et al. 2015). Here, ACTA1 is linked to Hepatic fibrosis.