CD4 and cancer: We found similar results with deconvolution algorithms: notably, negative correlations between pORG score and most lymphocyte subsets, as well as endothelial cells and cancer-associated fibroblasts, and positive correlations between pORG score and immune suppressive TH2 CD4+ T cells, macrophages, plasmacytoid dendritic cells and γδ T cells (Fig. 4a and Extended Data Fig. 6h).