ORACLE high-risk tumor regions were enriched (P < 0.05, odds ratio (OR) >1) in clonal mutations occurring in eight driver genes (PTPRB, TP53, MGA, KEAP1, SETD2, NOTCH2, ARID1A and NRAS) and depleted (P < 0.05, OR <1) in tumor regions with clonal mutations of EGFR or STK11 genes (Extended Data Fig. 9a,b). The gene discussed is SETD2; the disease is neoplasm.