The inhibition of miR-365 appears to normalize the abnormally prolonged AP in LQTS hiPSC-CMs by targeting KCNQ1, KCNH2, KCNJ2, CACNA1C, KCNC3, KCNA1, and KCNJ3, the dominating ion channel isoforms that determine cardiac repolarization, offering this miR as a potential therapy for the treatment of LQTS275. Here, CACNA1C is linked to familial long QT syndrome.