Additionally, our study contributes to the field of CRC by detailing the pivotal role of the FGR-PI3K-AKT-SP1 pathway in regulating DKK1 expression, thus broadening our knowledge of the molecular underpinnings of CRC and suggesting new directions for innovative therapeutic approaches, especially in improving the effectiveness of immunotherapies. The gene discussed is AKT1; the disease is colorectal carcinoma.