MAPK4 and AIDS: In contrast, core genes in the AIDS-ART group include TNFAIP3 (enriched in 10 pathways), associated with the negative regulation of lymphocyte activation; TRIM38 (enriched in 3 pathways), linked to the negative regulation of innate immune response; MAPK4 (enriched in 3 pathways), related to inflammasome complex assembly; and APOBEC3F (enriched in 2 pathways), associated with defense responses to viruses (Fig. 5b).